One of the most critical components of advancing a treatment into human clinical trials, is having a natural history study of the disease.  Natural history studies enable researchers to have a better understanding of the disease and how it progresses over time.  If you, or someone you know, has a diagnosis of SPG4 Hereditary Spastic Paraplegia, please consider participating in the natural history study at Boston Children’s Hospital.  Scientists are depending on you to provide them with the crucial data they need to move their findings into human clinical trials.