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Natural History Studies

One of the most critical components of advancing a treatment into human clinical trials is having a natural history study of the disease.  Natural history studies enable researchers to have a better understanding of the disease and how it progresses over time.


If you have a diagnosis of SPG4 Hereditary Spastic Paraplegia, we strongly encourage you to participate in a natural history study.  Scientists are depending on you to provide them with the crucial data they need to move their findings into clinical trials. 

Early Onset Hereditary Spastic Paraplegia (HSP)
Natural History Study


Boston Children's Hospital

  • Currently seeking individuals of all ages with:

    1.  Diagnosis of SPG4 Hereditary Spastic Paraplegia​

    2.  Symptom onset before age of 18

  • Participation is completely free and will be conducted over Zoom.  Patients all over the world are invited to participate.

Recent News

Stay up-to-date on the latest SPG4 news.

Science Class
NIH Intramural Research Program hosts virtual conference on
De Novo SPG4

NIH Videocast

Gene Therapy Offers Hope for Danish Girl

USA Today

ALS Neuron Damage Reversed With New Compound

Neuroscience News

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